top of page

Oxidative Stress

Studies and Research Papers

Oxidative 1
Screenshot 2020-09-13 at 4.34.41 PM.png

Astaxanthin in Cardiovascular Health and Disease

Astaxanthin and derivatives have been documented to have cardiovascular protective effects after prior administration both orally and intravenously and across several animal species. It also reduces...


Screenshot 2020-09-13 at 4.36.37 PM.png

Effects of Astaxanthin in Heart Failure Patients with Left Ventricular Systolic Dysfunction

Exercise capacity of heart failure patients with the left ventricular systolic dysfunction can be improved by 3 month astaxanthin supplementation...


Screenshot 2020-09-13 at 4.38.05 PM.png

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

Astaxanthin modulates immune response, inhibits cancer cell growth, reduces bacterial load and gastric inflammation, and protects against...


Screenshot 2020-09-13 at 4.40.02 PM.png

Dietary astaxanthin enhances immune response in dogs

Plasma concentrations of C reactive protein were lower in astaxanthin-fed dogs. Therefore, dietary astaxanthin heightened cell-mediated and humoral immune response and reduced DNA damage and inflamm...


Screenshot 2020-09-13 at 4.41.53 PM.png

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction

The results revealed that ASX treatment effectively ameliorated UUO-induced renal injury and dysfunction, inhibited renal fibrosis...


Screenshot 2020-09-13 at 4.43.51 PM.png

Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats

AST increased the nuclear content of Nrf2 and HO-1 and SOD1 protein expression and decreased the accumulation of FN and Col IV...


Oxidative 2
Screenshot 2020-09-13 at 4.52.04 PM.png

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction

ASX alleviates UUO-induced renal injury in mice Histopathological changes in the kidneys were determined by PAS staining. As...


Screenshot 2020-09-13 at 4.56.10 PM.png

Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications

The literature reviewed here clearly suggests a promising utilization of ASX in diabetes healthcare. ASX is a safe drug with pleiotropic effects and without crucial adverse effects. The...


Screenshot 2020-09-13 at 4.58.25 PM.png

The Protective Effects of Astaxanthin on the OVA-Induced Asthma Mice Model

In conclusion, all of the data in this experiment indicated that astaxanthin has a protective effect against OVA-induced allergic asthma mice. The exposure of the mice to astaxanthin...


Screenshot 2020-09-13 at 5.00.30 PM.png

Astaxanthin, Allergies & Skin

In summary, for those individuals with problems of metabolic syndrome, diabetes, hypertension, elevated cholesterol, atherosclerosis and prostate cancer or elevated PSA, I think it is prudent to add astaxanthin as a safe and potentially great health...


Screenshot 2020-09-13 at 5.03.49 PM.png

Astasanthin Proved Effective in Improving Chronic Obstructive Pulmonary Disease (COPD)

This study shows that astaxanthin increases antioxidant capacity in lung tissue and prevents emphysema. Astaxanthin is attracting attention as a new candidate substance for COPD...


Screenshot 2020-09-13 at 5.05.57 PM.png

Blood pressure-lowering effect of astaxanthin may help fight type 2 diabetes: Iran RCT

Astaxanthin supplementation may benefit type 2 diabetics by lowering their blood pressure and enhancing their glucose metabolism, say researchers in Iran...


Screenshot 2020-09-13 at 5.06.59 PM.png

High Dose Astaxanthin Lowers Blood Pressure and Increases Insulin Sensitivity in Rats: Are These Effects Interdependent?

In conclusion, astaxanthin was able to affect both the renin-angiotensin, nitric oxide and glucose-insulin systems at relatively high doses. This... 


Screenshot 2020-09-13 at 5.10.29 PM.png

Astaxanthin helps improve dysglycemia and blood pressure in patients with diabetes

New research just published demonstrated that astaxanthin suppl-

ementation improves glucose metabolism and decreases blood pressure in patients with type 2...


Screenshot 2020-09-13 at 5.13.31 PM.png

Astaxanthin – Powerful Antioxidant – Raises Good Cholesterol and Lowers Triglycerides

The results show that 12 to 18 mg doses per day significantly reduced triglyceride levels while 6 to 12 mg doses raised good cholesterol.  This ..


Screenshot 2020-09-13 at 5.15.21 PM.png

Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer’s Disease in APP/PS1 Double-Transgenic Mice

The findings suggested that AST-DHA attenuated cognitive disorders by reducing pathological features in...


Screenshot 2020-09-13 at 5.17.38 PM.png

Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer’s Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice

The present results indicated that astaxanthin decreased Aβ42...


Screenshot 2020-09-13 at 5.20.20 PM.png

Astaxanthin is neuroprotective in an aged mouse model of Parkinson’s disease

In conclusion, we have corroborated our previous findings that AXT is neuroprotective against MPTP induced neurotoxicity in young animals. We show that AXT preserves TH in the striatum and substantia...


Screenshot 2020-09-13 at 5.22.39 PM.png

Astaxanthin Attenuates Neurotoxicity in a Mouse Model of Parkinson’s disease

IBA-1 in the SN and striatum of AXT treated mice. Taken together, these studies suggest that AXT has neuroprotective property in the CNS against MPTP neurodegeneration...


Screenshot 2020-09-13 at 5.24.35 PM.png

Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes

These results suggest that astaxanthin supplementation results in improved erythrocyte antioxidant status and decreased PLOOH levels, which may contribute to the prevention of dem...


Screenshot 2020-09-13 at 5.27.23 PM.png

On the Neuroprotective Role of Astaxanthin: New Perspectives?

These researchers demonstrated that astaxanthin improved learning and decreased memory impairment and neuronal damage. Astaxanthin treatment increased the number of pyramidal neurons of the hippocam...


Screenshot 2020-09-13 at 5.28.38 PM.png

Effect of Astaxanthin on Cataract Formation Induced by Glucocorticoids in the Chick Embryo

Higher levels of AST prevented loss of reduced glutathione from the lens. These findings support that AST protects glucocorticoid-induced...


Screenshot 2020-09-13 at 5.30.42 PM.png

Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights

There is a growing body of evidence suggesting the beneficial pleiotropic effects of astaxanthin in the prevention and treatment of several..


Screenshot 2020-09-13 at 5.34.16 PM.png

Astaxanthin Mediates Inflammation Biomarkers Associated with Arthritis in Human Chondrosarcoma Cells Induced with Interleukin-1β

In conclusion, astaxanthin accumulates in SW-1353 human chondrosarcoma cells and incubatio... 


Screenshot 2020-09-13 at 5.37.10 PM.png

The P0wer of Astaxantin

Astaxanthin may improve the skin condition of both men and women, those with inflammatory skin problems, pigmentation or just aging skin. Natural, food-sourced astaxanthin is best and the form that has been tested and approved by the...


Screenshot 2020-09-13 at 5.41.01 PM.png

Cosmetic benefits of astaxanthin on humans subjects*

In conclusion these results may suggest that astaxanthin derived from H. pluvialis can improve skin condition in all layers such as corneocyte layer, epidermis, basal layer and dermis by

combining both oral supplementatio...


Screenshot 2020-09-13 at 5.42.11 PM.png

Astaxanthin from Haematococcus pluvialis Prevents Oxidative Stress on Human Endothelial Cells without Toxicity

Astaxanthin has been demonstrated here to inhibit intracellular induced stress in human endothelial cells without any cytotoxicity and...


Screenshot 2020-09-13 at 5.44.31 PM.png

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

Overall, this study shows that dietary astaxanthin enhanced immune response, and decreased a DNA oxidative damage biomarker and ...


Screenshot 2020-09-13 at 5.46.16 PM.png

Oxidative Stress Regulation on Endothelial Cells by Hydrophilic Astaxanthin Complex: Chemical, Biological, and Molecular Antioxidant Activity Evaluation

The use of carotenoids like antioxidants can assist the natural mechanisms of cells in neutralizing ...


Screenshot 2020-09-13 at 5.47.45 PM.png

Astaxanthin Attenuates Homocysteine-Induced Cardiotoxicity in Vitro and in Vivo by Inhibiting Mitochondrial Dysfunction and Oxidative Damage

Taken together, our results demonstrated that ATX suppressed...


Screenshot 2020-09-13 at 5.49.42 PM.png

Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats

The protective effect of astaxanthin was associated with reduction of free radicals by improving antioxidant enzyme function, as well as ...


Screenshot 2020-09-13 at 5.51.00 PM.png

Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice

Therapy with astaxanthin directed toward activating the Nrf2 pathway has the potential to be a novel preventive and therapeutic strategy for COPD...



Guardian of Organs



bottom of page